Heart Pump Strong


The human heart is possibly the most important part of our body. It beats around 70 times per minute, pumping a little more than 2.5 ounces of blood per stroke and around 2,000 gallons of oxygenized blood throughout the body every single day.

Risk Factors for Angina

• Tobacco use
• Diabetes
• High blood pressure
• High blood cholesterol or triglyceride levels
• History of heart disease
• Older age
• Lack of exercise
• Obesity
• Stress

Doctors aim to reduce symptoms and lower the risk for a heart attack by using medications, various medical procedures and lifestyle change recommendations (as with a healthy diet, leading an active lifestyle, quitting smoking and avoiding angina trigger activities).

In some cases, despite interventional procedures and medications, angina symptoms may continue to present themselves and even worsen. Patients experiencing such progression of the condition may be candidates for the Rejuvenare Cell Therapy.

Angina Treatment and Diagnosis

As is the case with many conditions, early detection can greatly affect the prognosis. To do this, your cardiologist will most likely use one of the following tests to determine type of angina and the cause for it in patients:

• Chest X-Rays
• Blood Analysis
• Electrocardiogram (EKG) to record electrical impulses in the heart and monitor oxygenation of the heart
• Stress Tests – which are heart reading while the patient is performing physical effort.

Angina is caused by a reduced blood flow to the heart muscle. Blood carries oxygen-rich blood, which the heart muscle and cells need to survive. When the heart is oxygen deprived, it causes the condition known as ischemia.

The most common cause for the reduced blood flow to the hearts muscle is Coronary Artery Disease (CAD), which, if allowed to worsen, can result in heart attacks, and other serious cardiac conditions.

Common Angina Symptoms

Chest pain, the most common angina symptom, may be described as pressure, squeezing or pain in the center of the chest. Some people with angina describe the symptoms as the feeling of a heavy weight being placed on their chest. For others, it may feel like indigestion or heartburn.

Other symptoms can come in the form of:

• Shortness of breath
• Nausea
• Cramps
• Aching behind the breast bone
• Pain spreading to the shoulders, neck, back or jaw

The manifestation of discomfort associated with this condition is referred to as an “angina attack” and the duration and type of angina can vary:

Stable Angina or chronic angina

• Develops when your heart works harder, such as when you exercise.
• Can usually be predicted and the pain is usually similar to previous types of chest pain you have experienced.
• Lasts a short time (5 minutes or less)
• Disappears sooner if you rest or use angina medication.

Unstable Angina (this is a medical emergency)

• Occurs even at rest
• This is a change in your usual pattern of angina
• Is unexpected
• Is usually more severe and lasts longer than stable angina (it can last as long as 30 min)
• May not disappear by resting or by using angina medication
• Might signal a heart attack

Variant Angina or Prinzmetal’s angina

• It is caused by a spasm in a coronary artery in which the artery temporarily narrows.
• It can occur even at rest and is often severe
• It can be relieved with medications

What does stem cell therapy do for Angina?

Rejuvenare’s Stem Cell therapy starts after a 20-minute harvesting procedure, where we extract adult stem cells from a patient’s bone marrow and then process the cells with our proprietary protocols.

Our results have shown strong improvements on patient symptoms by the following measured benefits:

• Increased quality of life
• Lowered cardiac mortality rate
• Reduced angina

What is Angina

Angina is a condition marked by severe pain in the chest directly caused by an insufficient supply of oxygen-rich blood to the heart, but the pain also often spreads to the shoulders, arms and neck.

Even though Angina is more the symptom of an underlying cardiac condition than a disease itself (usually CAD), it is treated, as it’s own condition due to the prevalence amongst cardiac patients.

Improving heart function with Rejuvenare Cardiac Cell Therapy

Rejuvenare’s Cardiac Stem Cell therapy uses adult stem cells harvested from patients’ own bone marrow and implanted into the portions of the heart presenting signs of ischemia or decreased blood flow. In Rejuvenare’s experience of more than 9000 patients treated, these cells have been seen to achieve positive results in post-heart attack patients and those experiencing angina or heart failure.

Even though stem cell treatments for all forms of cardiomyopathy have not yet been completely researched, patients suffering ischemic cardiomyopathy and other diseases related to blood-flow issues, have made incredibly positive improvements.

However, in we do not take any patients who we don’t wholeheartedly think that we cannot help, that are the reason why we review each patient case by case to determine patient candidacy.

Common Cardiomyopathy Treatments

The most common and traditional treatments for cardiomyopathy made available by modern medicine are:

• Medications (blood thinners, diuretics, etc.)
• Lifestyle changes (including diet and exercise)
• Surgery (such as stents or bypass surgery)
• Implanted devices (pacemaker, etc.)

Depending on what specific condition a patient suffers, these different options aim to reduce symptoms of cardiomyopathy and diminish the risk of complications.

What are the general cardiomyopathy symptoms?

• Shortness of breath with exertion or even at rest
• Edema (swelling of legs/ankles/feet)
• Angina (chest pain)
• Excessive fatigue
• Bloating of the abdomen due to fluid buildup
• Cough while lying down
• Irregular heartbeats that feel rapid or pounding
• Chest pain
• Dizziness

Even though some patients show no symptoms, no matter the type of cardiomyopathy you have, signs and symptoms ten to get worse if left untreated, and, as this disease worsens, the heart becomes progressively weaker and unable to maintain consistent pumping rhythm which can ultimately degenerate into heart failure.

Common types of Cardiomyopathy

Dilated cardiomyopathy (DCM)

Patients with DCM suffer from a abnormally enlarged heart. The disease causes the chambers of the heart to enlarge, which eventually leads to heart failure due to the fact that the heart can no longer pump blood efficiently to the rest of the body. DCM can be caused by a number of different factors but not limited to:

• Various Viruses
• Post-partum conditions
• A leaky aortic valve

Ischemic Cardiomyopathy (ICM)

When blood flow to the heart is cut off (ischemia), the heart’s pumping chamber becomes enlarged and weak. This is usually seen in patients who have had heart attacks or who have coronary artery disease. Ischemic cardiomyopathy is a type of dilated cardiomyopathy.

Hypertrophic Cardiomyopathy (HCM)

Also sometimes referred to as “obstructive cardiomyopathy”, HCM can be familial or passed down through genetics. In an obstructive form of HCM, the heart’s blood flow capacity is affected by the hardening of the myocardium (heart muscles).

What does Stem Cell therapy do for cardiomyopathy?

Rejuvenare’s Cardiac Stem Cell therapy has been very effective in reducing and sometimes reversing damage from a heart attack as well as improving heart function when certain cell types are used.

Throughout our more than 9000 treated patients, we have seen significant improvement in heart function and symptoms in patients with ischemic cardiomyopathy and more so in patients suffering ischemic cardiomyopathy. This results from increased blood flow, reduced inflammation and the reversal of cell death in heart muscle.

Symptoms for congestive heart failure can vary

Symptoms can significantly vary from one patient to another and they depend on factors such as; other existing conditions, how early they were detected, level of physical activity and diet.

However, some of the most commonly reported:

• Chest pains
• Shortness of breath
• Fatigue
• Water retention
• Swollen limbs

Present day medicine treats congestive heart failure in a number of different ways like:

• Surgery
• Medications
• Diet
• Exercise

Sadly these conventional treatments prove to be ineffective for many patients who are left with a congested heart and branded as “no-option patients”.

Rejuvenare’s Cardiac Cell Therapy provides a new option

What does stem cell therapy do for heart failure?

Even though this condition itself cannot be cured, heart failure symptoms can be very easily managed and reduced with Rejuvenare’s Stem Cell Therapy.

Rejuvenare’s treatment rests on more than 60 years of research Stem Cell therapies utilizing bone marrow harvests. We have perfected processing and delivery protocols to further refine and take the most advantage of harvested material.

Patients will experience an improved blood flow to their hearts, which on it’s own significantly betters heart function. Less than six months after implantation, patients with damaged heart tissue showed a significant reduction in the infarct zone. This not only reduces visible symptoms such as regeneration of damaged tissue, but improves blood flow and recuses ischemia.

Adult stem cells can enable the heart to repair itself

Adult stem cells harvested from the bone marrow are rich in anti-inflammatory components that stimulate new blood vessel growth. Oxygen-rich blood will pump through these “old” now-cleared up vessels and through other new pathways so that the heart muscle can begin the process of repairing itself.

What does stem cell therapy do for C.A.D.?

When they are placed in a low-oxygen environment, Rejuvenare’s stem cells transform to become more vascular in orientation, and they also release various growth factors, which significantly aid in the healing process.

Once the processed stem cells are implanted directly to the heart using a catheter through the carotid artery via Rejuvenare’s proprietary delivery protocols,

As mentioned before, the above treatments offered my mainstream medicine today only serve often as a temporary solution to the problem, and, once patients have exhausted those alternatives, they become labeled as “no-option heart patients”. This means that there is nothing medicine can do to help them in their current state, as some patients may not be qualified to undergo heart transplantation, while others might not be matched with a donor in time.

In the past, exhaustion of these traditional cardiac treatment options meant being labeled as a “no-option” heart patient. Further, some patients may be unable to undergo heart transplantation while others may not be matched with a donor heart in time. Despite the use of current available treatments, these “no-option” patients experience deterioration in their quality of life, and their life expectancy shortens.

Rejuvenare therapy utilizes stem cells obtained from the patient’s own bone marrow. These cells are placed back directly into the patient’s heart via a catheter using Rejuvenare’s proprietary delivery protocols, where they prompt the growth of new blood vessels. This non-invasive procedure can restore normal blood flow to the heart thus greatly improving heart function.

Rejuvenare has had great results with many documented cases for heart procedures utilizing processed stem cells delivered by our proprietary protocols, bringing new hope for coronary artery disease patients.

Coronary Artery Disease treatment options

When CAD is diagnosed in it’s early stages, it can be managed by incurring in healthier lifestyle changes, such as quit smoking, exercising more and committing to a balanced diet.

On the other hand, various drugs can be used to treat CAD, including Cholesterol-modifying medications, aspirin and beta-blockers, the objective being to prevent further progression of the coronary artery blockages and preventing future heart attacks that could further damage the heart muscle.

However, if this approach proves unsuccessful, a more aggressive treatment is needed and an angioplasty is performed – the doctors threads a thin tube, inserted through a blood vessel in the arm or groin up to the artery where the blockage is presented. The tube contains a small balloon, which is inflated to push plaque outward against the wall of the artery. This widens the artery and restores blood flow.

By-pass surgery – A major surgery where the doctors grafts a the patient’s vein or uses a piece of plastic graft to by-pass the blockage and redirect blood flow around the obstruction.

The problem with said procedures is that many times they act as a temporary fix and it addresses a specific blockage in a specific tract of artery.

Coronary Artery Disease symptoms

When the coronary arteries narrow, they are unable to supply enough oxygen-rich blood to the heart, especially when it’s beating hard. As more plaque builds up and lines the walls of the arteries, blood flow becomes increasingly suppressed and symptoms start to surface.

Normally patients start by feeling chest pain (angina) triggered by physical or emotional stress, manifested as a pressure or tightness in the chest, as if someone were standing on it.

There is also a constant “shortness of breath” and fatigue since the heart can’t pump enough blood to meet the body’s needs.

Finally, when plaque builds up inside the artery and eventually completely blocks it a heart attack occurs.

What is Coronary Artery Disease?

Coronary Artery Disease (CAD) happens when a waxy substance called plaque builds up inside the coronary arteries, which are in charge of supplying oxygen-rich blood to your heart muscle. When the arteries finally become blocked, neighboring organs can become damaged as the heart muscle struggles to function normally due to a repressed blood-flow (this is called ischemia).

Compromised heart function can have devastating effects on the entire body. Narrowed arteries in the heart (CAD) gradually leave your heart too weak or stiff to fill and pump blood efficiently, so Coronary artery disease progresses into a condition known as Congestive Heart Failure, where a chronic condition might develop or an acute heart failure can occur.

What does stem cell therapy do for heart attack damage?

Medication and lifestyle changes go a long way in the treatment of heart attacks, but it is simply not enough. Rejuvenare’s Stem Cell therapy brings and alternative to actually improve the patient’s quality of life by:

• Reducing chest pains (angina)
• Decreasing (scar tissue) size
• Improved consumption and use of oxygen

Adult stem cells harvested from your own bone marrow and implanted by our revolutionary delivery protocols stimulates the growth of new blood vessels and promotes tissue regeneration, constraining further cell death, and actually decreasing the size of the infarction.

Signs and symptoms of a heart attack

When a heart attack his, most individuals experience on of the following

• Pressure, tightness, pain or squeezing in the chest and arms that may actually spread to your neck, jaw or back.
• Nausea, indigestion or vomiting
• Shortness of breath
• Cold sweat
• Fatigue

Even though normally the person suffering the MI would feel pain that irradiates from the chest, this is not always the case, and a person can even have a asymptomatic heart attack. Not all people who have heart attacks have the same symptoms or have the same severity of symptoms.

What is a myocardial infarctions?

Myocardial Infarction (or MI) is the medical term for what is commonly known as a “heart attack” and it occurs when the flow of blood to the heart is blocked completely. This interrupted blood flow can virtually destroy most of the heart, since oxygen-rich blood does not reach muscle cells in time essentially starving them to death.

The affected area left behind after a heart attack, where muscle cells die or become damaged, is called an infarction – a wound area of scar tissue, which is not even contained to stay in the heart, it can actually spread to involve other areas of the heart where the blood supply is also limited.

Signs and symptoms of cardia ischemia

When signs and symptoms of ischemia, a restricted blood flow to the heart occurs, some patients might experience signs and symptoms – usually on the left side of the body (angina pectoris) – while other might not experience anything at all (this is called silent ischemia).

Blockages in the arteries, usually obstructions caused by plaque buildup in the arterial walls, prevent the heart from receiving a sufficient supply of blood. This prevents oxygen-rich blood from getting to the heart muscles, causing tissue death and chest pains (angina), which is usually the primary manifestation of ischemia.

Other signs and symptoms, which can be experienced by older people, people with diabetes and women include:

• Neck/jaw pain
• Shoulder or arm pain
• Shortness of breath when you are physically active
• Nausea and even vomiting
• Sweating
• Fatigue

What does stem cell therapy do for ischemic heart disease?

Rejuvenare Stem Cell Therapy directly targets damaged heart tissue. Not only does it stimulate the growth of brand new blood vessels, creating new pathways for blood, but also restores and regenerates damaged heart tissue, reestablishing its ability to pump blood strongly throughout the body and thus improve a patient’s quality of life.

Our ample experience with cardiac treatments have shown patients to experience improvement on all of the following key measurements for cardiac performance which ultimately leads to better heart function:

• Improved oxygenation of blood.
• Increased physical strength.
• A significant reduction in the percentage of damaged heart tissue.
• Reduced Angina.

What is ischemia?

“Ischemia” refers to the condition in which there is an inadequate blood supply to an organ or any part of the body (particularly the heart).

Myocardial ischemia will eventually and irreparably damage the heart muscle, reducing its ability to pump efficiently and it is usually the result of another heart condition such as CAD, where blocked arteries prevent the heart muscle from receiving a healthy supply of oxygen rich blood which results in cell death.

Ischemia progressively and irreparably weakens heart muscle, compromising its ability to pump blood, which eventually leads to heart failure.

What does stem cell therapy do for P.A.D.?

When they are placed in a low-oxygen environment, Rejuvenare’s stem cells transform to become more vascular in orientation, and they also release various growth factors, which significantly help the healing process.

Rejuvenare treatment not only targets the affected ischemic area, but also stimulates the growth of new blood vessels using autologous stem cells. Such a process can restore flow to the limbs, heart and brain, thus improve a patient’s quality of life to the point where they can become active again, walk without pain, and carry out normal day-to-day activities and care for themselves.

Clinical results show that adult stem cells based on the Rejuvenare protocol are not only safe, but significantly lowers the incidence of amputation, wound worsening and eventual death.

Common P.A.D. treatments

Up to this point, if a doctor is presented with a patient who suffers with P.A.D. one of two approaches will be taken;

Angioplasty – the doctors threads a thin tube, inserted through a blood vessel in the arm or groin up to the artery where the blockage is presented. The tube contains a small balloon, which is inflated to push plaque outward against the wall of the artery. This widens the artery and restores blood flow.

By-pass surgery – A major surgery where the doctors grafts a the patient’s vein or uses a piece of plastic graft to by-pass the blockage and redirect blood flow around the obstruction.

The problem with said procedures is that many times they act as a temporary fix and it addresses a specific blockage in a specific tract of artery.

Peripheral artery disease symptoms

P.A.D. Produces mild, or no symptoms at all in most people. Normally, people suffer fleeting muscle pain or cramps in the leg while walking and even this disappears after a few minutes of rest. Other symptoms might include:

• Cramping in hip, thigh or calf muscles after walking or climbing stairs.
• Leg numbness or weakness
• Coldness in your lower leg or foot, especially when compared to other side.
• Sores on your toes, feet or legs that won’t heal.
• A change in the color of your legs.
• Hair loss or slower hair growth on your feet and legs.
• Slower growth of toenails
• Shiny skin on your legs
• No pulse or a weak pulse in legs or feet
• Erectile dysfunction in men.

What is peripheral artery disease?

Peripheral artery disease (P.A.D) happens when plaque (made up of fat, cholesterol, calcium, fibrous tissue and other substances found in the blood) builds up and lines the walls of the arteries in charge of carrying oxygenated blood to your head, organs and limbs, thus drastically reducing the blood flow. This is called atherosclerosis.

Once plaque starts building up and lining the arteries and causing Peripheral Artery Disease, you’re at risk of developing:

• Critical Limb Ischemia, which begins as open sores that don’t heal. It might also appear as an injury or an infection to patient’s feet or legs. Critical Limb ischemia occurs when these injuries or infections progress to such point when they cause gangrenous tissue to form. This means that the tissue in that area dies and when this progresses sometimes the amputation toe the affected limb is required.

• Stroke and heart attack. The atherosclerosis that causes the symptoms of peripheral artery disease, don’t just compromise limbs and extremities, fat deposits also build up in arteries supplying oxygenated blood to the heart and brain.

Targeting Symptoms

Heart disease manifests in different ways for each patient, but many with severe heart conditions like coronary artery disease or congestive heart failure experience:

• Persistent Fatigue
• Shortness of breath
• Regular chest pains (angina)
• Limitations on exercise and other physical activity

Cell therapy not only targets these symptoms to provide relief but also, through the restorative mechanisms of the stem cells themselves, works to repair the heart for better pumping functions. This equates to better breathing, improved ability to exercise or perform physical activity as well as reduced chest pains and improved energy levels.

Improving Function

Adult stem cells could be thought of as small “doctors” who go work healing and repairing the body on a daily basis. Stem cells exist throughout our bodies in various tissues and are responsible for healing cuts and bruises and helping us recover from the every day wear and tear.

During your cardiac cell therapy, adult stem cells will be delivered to your heart through a catheter; however, they will not stay there for more than a few days. Fascinatingly, during their brief time in and around your damaged heart muscles, these cell “doctors” secrete proteins and growth factors, and we eventually begin to see them turn around on the heart’s native ability to repair itself.

Entering the Heart

The stem cells, which reside in your own bone marrow, have a few important functions that are of a particular interest to a healing damaged heart.

• Your own adult stem cells stimulate the growth of new blood vessels, a process known as angiogenesis, which leads to improved blood flow in the heart.
• These cells also provide an anti-inflammatory effect, which aids in ‘the repairing of the heart’.
• Further, they attach themselves to damaged tissue and recruit other cells necessary for repairing and replacing damaged heart tissue.
• Adult stem cells also aid in reducing the size of the scar tissue, which forms on the heart after a heart attack.
• Last, but not least, your own cells can prevent continued heart muscle cell death (a process known as apoptosis).

The Procedure

Before any part of the actual procedure is done, the prospect patient must undergo an evaluation by Rejuvenare’s medical team to assess the their particular case and determine if he or she could be a candidate to later be later invited for treatment. Rejuvenare’s doctors will evaluate the patient’s current lab works and clinical and surgical history before anything else is done.

The whole procedure takes place over the course of three days in a clinical outpatient setting and there is little to no down time afterwards as all is done with local anesthesia.

First day – the patient undergoes an initial evaluation and blood work by Rejuvenare’s doctor. (1.5 hours). The patient is later sent to rest to their hotel.

Second day – The patient is transferred to the hospital at 6am to meet Rejuvenare’s team of hematologists for the harvesting of the bone marrow from the heleatic crest (or hip bone),, a painless 30 min procedure done under local anesthesia Approximately 300 ml of bone marrow will be harvested from the patient and will be immediately sent out to the lab to be processed with Rejuvenare’s proprietary technology while the patient is sent to his room to wait for his own processed cells to be ready for implantation.

At 2pm the powerful processed adult autologous stem cells are ready to be implanted via Rejuvenare’s revolutionary delivery protocols. This procedure takes less than 40 minutes under local anesthesia and will follow the protocols formulated by Rejuvenare’s medical team specifically for the patient and their particular condition.

Following the implant of cells, the patient is sent to rest.

Later this same evening, Rejuvenare’s doctors will assess the patient for discharge, and when released from the hospital, he/she will be transferred back to the hotel.

The patient is encouraged to rest and refrain from doing any strenuous activities.

Third day – On this day, the patient resumes their normal activities. They should try to rest and stay hydrated.

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